Professor David S.H. Wong
 Chair Professor and Head
Albert Bing Ching Young Chair Professor in Ophthalmology
Cluster Chief of Service (Ophthalmology), Hong Kong West Cluster, Hospital Authority

Tel no. : (852) 3962 1413
Email : shdwong@hku.hk

MBChB (Liverpool) ; FRCS (Eng)
FRCP (UK) ; FRCOphth

Dr. David Wong

Research Interests :

Age-related macular degeneration (AMD)

I have been developing surgery for AMD and its complications. The disease is characterised by new blood vessels forming underneath the retina. The natural history involves leakage from the blood vessels, haemorrhage and ultimately a fibrovascular scar. As a result of this process, there is destruction of the photoreceptors. We postulated that the new blood vessels form as a result of vasculogenesis as oppose to angiogenesis. Our study showed AC133 positive cells in the fibrovascular membranes removed at surgery indicating that bone marrow derived stem cells are involved in the neovascularisation.

Reference

  1. Wong D, Lois N. Foveal relocation by redistribution of the neurosensory retina. Br J Ophthalmol 2000;84(4):352-7.

  2. Wong D, Stanga P, Briggs M, Lenfestey P, Lancaster E, Li K, et al. Case selection in macular relocation surgery for age related macular degeneration. Br J Ophthalmol 2004;88(2):186-90

  3. Sheridan CM, Rice D, Hiscott PS, Wong D, Kent DL. The presence of AC133-positive cells suggests a possible role of endothelial progenitor cells in the formation of choroidal neovascularization. Invest Ophthalmol Vis Sci 2006;47(4):1642-8

AMD

Top
 

Retinal Detachment and Proliferative Vitreoretinopathy (PVR)

Retinal Detachment is associated with high myopia and there is a familial predisposition. Most retinal detachments occur spontaneously and are caused by a combination of intraocular currents, vitreous traction and the presence of retinal tears. Patients present with floaters sometimes referred to as Muscae
volitantes (Latin: 'flying flies').

Once a detachment occurs the eye undergoes a modified healing process involving cellular proliferation, tissue contraction and laying down of collagen; this is referred to as Proliferative vitreoretinopathy (PVR). Unlike diabetic retinopathy, neovascularisation is not a feature. PVR is the main reason why surgery is unsuccessful in up to 15% of all patients. Several earnest attempts have been made to use antimetabolites to control this wound healing process and increase the success rate of surgery.

References

  1. Asaria RH, Kon CH, Bunce C, Charteris DG, Wong D, Khaw PT, Aylward GW. Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy : Results from a randomized, double- blind, controlled clinical trial. Ophthalmology 2001;108(7):1179-83.

  2. Asaria RH, Kon CH, Bunce C, Charteris DG, Wong D, Luthert PJ, Khaw PT, Aylward GW. How to predict proliferative vitreoretinopathy: a prospective study. Ophthalmology 2001;108(7):1184-6.

  3. Hagan S, Hiscott P, Sheridan CM, Wong D, Grierson I, McGalliard J. Effects of the matricellular protein SPARC on human retinal pigment epithelial cell behavior. Mol Vis 2003;9:87-92.

  4. Charteris DG, Aylward GW, Wong D, Groenewald C, Asaria RH, Bunce C. A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established
    proliferative vitreoretinopathy. Ophthalmology 2004;111(12):2240-5.

Top
Publications List (2006 - 2009):

Books

  1. Kirchhoff B, Wong D (Editors) Vitreoretinal Surgery: Book in Series ‘Essentials of Ophthalmology’ by Verlag Springer. 2nd Edition. 2006

  2. R. Williams, D Wong. Ophthalmic Biomaterials. December 15 2008.

Top

2009

  1. Wong D, Kumar I, Quah SA, Ali H, Valdeperas X, Romano MR. Comparison of postoperative intraocular pressure in patients with Densiron-68 vs conventional silicone oil: a case-control study. Eye. 2009 Jan;23(1):245. No abstract available. PMID: 19148164 [PubMed - in process]

Top

2008

  1. Lam RF, Cheung BT, Yuen CY, Wong D, Lam DS, Lai WW. Retinal Redetachment after Silicone Oil Removal in Proliferative Vitreoretinopathy: A Prognostic Factor Analysis. Am J Ophthalmol. 2008 Jan 10; [Epub ahead of print] PMID: 18191093 [PubMed - as supplied by publisher]

  2. Bartz-Schmidt U, Szurman P, Wong D, Kirchhof B. [New developments in retinal detachment surgery] Ophthalmologe. 2008 Jan;105(1):27-36. Review. German. PMID: 18210123 [PubMed - indexed for MEDLINE]

  3. Wong D, Liazos S, Mehta J, Farnell DJ. Macular translocation surgery: computer simulation of visual perception. Graefes Arch Clin Exp Ophthalmol. 2008 Jun;246(6):831-6. Epub 2008 Feb 20. PMID: 18286298 [PubMed - indexed for MEDLINE]

  4. Stappler T, Heimann H, Wong D, Gibran SK, Groenewald C, Pearce IA. Heavy tamponade 2 Densiron 68(R) in routine clinical practice: anatomical and functional outcomes of a consecutive case series. Eye. 2008 Feb 29. [Epub ahead of print] PMID: 18309331 [PubMed - as supplied by publisher]

  5. Heimann H, Stappler T, Wong D. Heavy tamponade 1: a review of indications, use, and complications. Eye. 2008 Mar 14. [Epub ahead of print] PMID: 18344952 [PubMed - as supplied by publisher]

  6. Stappler T, Williams R, Gibran SK, Liazos E, Wong D. A guide to the removal of heavy silicone oil. Br J Ophthalmol. 2008 Jun;92(6):844-7. Epub 2008 May 6. PMID: 18460540 [PubMed - indexed for MEDLINE]

  7. Romano MR, Stappler T, Marticorena J, Groenewald C, Pearce I, Gibran SK, Wong D, Heimann H. Primary vitrectomy with Densiron-68 for rhegmatogenous retinal detachment. Graefes Arch Clin Exp Ophthalmol. 2008 Jul 11. [Epub ahead of print] PMID: 18618126 [PubMed - as supplied by publisher]

  8. Lai WW, Wong D, Li KK, Leow PL. Emulsification and inverted hypopyon formation of oxane HD in the anterior chamber. Graefes Arch Clin Exp Ophthalmol. 2008 Nov;246(11):1633-5. Epub 2008 Jun 11. PMID: 18546011 [PubMed - in process]

  9. Stappler T, Heimann H, Gibran SK, Groenewald C, Pearce IA, Wong D. [Densiron-68 heavy silicone oil in cases of PVR: Anatomic and functional outcomes.] Ophthalmologe. 2008 Jul 19. [Epub ahead of print] German. PMID: 18636266 [PubMed - as supplied by publisher]

  10. Hemmerdinger C, Wong D. Management of Age Related Macular Degeneration. Clinical Focus Primary Care - For Practitioners with Special Interest. 2008 3(1): 18-23.

  11. Joussen AM, Wong D. The concept of heavy tamponades—chances and limitations. Graefe's Archive for Clinical and Experimental Ophthalmology. Accepted: 30 April 2008 Published online: 11 June 2008.

  12. Li KK, Lai JS, Wong D. Reply. Retina 2008;28(2):366-367.

  13. Wong D, Li KK. Avastin in myopic choroidal neovascularisation: is age the limit? Br J Ophthalmol. 2008 Aug;92(8):1011-2. No abstract available. PMID: 18653589 [PubMed - indexed for MEDLINE]

  14. Syed K. Gibran, Mario R. Romano, David Wong. Surgical Management Of Massive Sub-Macular Hemorrhage Associated With Age-Related Macular Degeneration. Retinal Cases & Brief Reports 2008.

  15. Gibran SK, Romano MR, Wong D. Perfluorocarbon liquid assisted large retinal epithelium patching in sub-macular hemorrhage secondary to age related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2009 Feb;247(2):187-91. Epub 2008 Oct 17. PMID: 18925410 [PubMed - in process]

  16. Saeed MU, Heimann H, Wong D, Gibran SK. Heavy silicone oil tamponade after failed macular hole surgery with perfluoropropane (C(3)F (8)): a report of five cases. Graefes Arch Clin Exp Ophthalmol. 2008 Oct 30. [Epub ahead of print] PMID: 18972124 [PubMed - as supplied by publisher]

  17. Romano MR, Gibran SK, Marticorena J, Wong D, Heimann H. Can a preoperative bevacizumab injection prevent recurrent postvitrectomy diabetic vitreous haemorrhage? Eye. 2008 Nov 28. [Epub ahead of print] PMID: 19039332 [PubMed - as supplied by publisher]

  18. Lee M, Lo AC, Cheung PT, Wong D, Chan BP. Drug carrier systems based on collagen-alginate composite structures for improving the performance of GDNF-secreting HEK293 cells. Biomaterials. 2009 Feb;30(6):1214-21. Epub 2008 Dec 6. PMID: 19059641 [PubMed - in process]

  19. Li SY, Fu ZJ, Ma H, Jang WC, So KF, Wong D, Lo AC. Lutein rescued retinal neurons and decreased oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci. 2008 Oct 20. [Epub ahead of print] PMID: 18936152 [PubMed - as supplied by publisher]

  20. Spitzer MS, Kaczmarek RT, Yoeruek E, Petermeier K, Wong D, Heimann H, Jaissle GB, Bartz-Schmidt KU, Szurman P. The Distribution, Release Kinetics, and Biocompatibility of Triamcinolone Injected and Dispersed in Silicone Oil. Invest Ophthalmol Vis Sci. 2008 Dec 20. [Epub ahead of print] PMID: 19098319 [PubMed - as supplied by publisher]

  21. Li KK, Yuen HK, Lai JS, Wong D. Does the internal limiting membrane regenerate? Clin Experiment Ophthalmol. 2008 Aug;36(6):579-80. No abstract available. PMID: 18954322 [PubMed - in process]

Top

2007

  1. Saeed MU, Wong D, Heimann H, Gibran SK. Spontaneous progressive supra-choroidal haemorrhage in a patient undergoing haemodialysis [2]. Graefe's Archive for Clinical and Experimental Ophthalmology 2007;245(11):1741-1742.

  2. Joussen AM, Kirchhof B, Schrage N, Ocklenburg C, Hilgers RD, Kirchhof B, et al. Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications. Acta Ophthalmologica Scandinavica 2007;85(6):623-630.

  3. Gibran SK, Kenawy N, Wong D. Treatment of exposed explants with donor sclera and amniotic membrane [3]. Graefe's Archive for Clinical and Experimental Ophthalmology 2007;245(6):915-916.

  4. Li KKW, Lai JSM, Wong D. Double macular hole in vitreomacular traction syndrome. Retina 2007;27(5):648-650.

  5. Gibran SK, Sachdev A, Stappler T, Newsome R, Wong D, Hiscott P. Histological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin). British Journal of Ophthalmology 2007;91(5):602-604.

  6. Gibran SK, Kenawy N, Wong D, Hiscott P. Changes in the retinal inner limiting membrane associated with Valsalva retinopathy [12]. British Journal of Ophthalmology 2007;91(5):701-702.

  7. Wickham L, Bunce C, Wong D, McGurn D, Charteris DG. Randomized Controlled Trial of Combined 5-Fluorouracil and Low-Molecular-Weight Heparin in the Management of Unselected Rhegmatogenous Retinal Detachments Undergoing Primary Vitrectomy. Ophthalmology 2007;114(4):698-704.

  8. Osborne SF, Williams R, Batterbury M, Wong D. Does the surface property of a disposable applanation tonometer account for its underestimation of intraocular pressure when compared with the Goldmann tonometer? Graefe's Archive for Clinical and Experimental Ophthalmology 2007;245(4):555-559.

  9. Wong D, Durnian JM. Surgical treatment of age-related macular degeneration: Will there be a role in the future? Clinical and Experimental Ophthalmology 2007;35(2):167-173.

  10. Dhingra N, Pearce I, Wong D. Early vitrectomy for fundus-obscuring dense vitreous haemorrhage from presumptive retinal tears. Graefe's Archive for Clinical and Experimental Ophthalmology 2007;245(2):301-304.

  11. Gibran SK, Prime W, Cazabon J, Stappler T, Heimann H, Pearce I, et al. Successful retrieval of internal limiting membrane specimens [41]. Eye 2007;21(2):298-299.

  12. Sahni J, Stanga P, Wong D, Lenfestey P, Kent D, Harding S. Optical coherence tomography analysis of bilateral end-stage choroidal neovascularization where one eye is treated with photodynamic therapy. Clinical and Experimental Ophthalmology 2007;35(1):13-17.

  13. Wong D. Doctors Know Best. Eye News. 2007; 13(7): 36-9.

  14. Li KK, Tang EW, Lai JS, Wong D. Pseudomonas aeruginosa choroidal abscess in a patient with bronchiectasis. Int Ophthalmol. 2007 Aug 9; [Epub ahead of print] PMID: 17687520 [PubMed - as supplied by publisher]

  15. Gibran S, Fleming B, Stappler T, Pearce I, Groenewald C, Heimann H, Hiscott P, Wong D. Peel and Peel again. Br J Ophthalmol. 2007 Nov 30; [Epub ahead of print] MID: 18055573 [PubMed - as supplied by publisher]

  16. Li KK, Wong D. Avoiding retinal slippage during macular translocation surgery with 360 retinotomy. Graefes Arch Clin Exp Ophthalmol. 2007 Nov 15; [Epub ahead of print] PMID: 18004588 [PubMed - as supplied by publisher]

  17. Valldeperas X, Wong D. Is it worth reoperating on macular holes? Ophthalmology. 2008 Jan;115(1):158-63. Epub 2007 May 18. PMID: 17512597 [PubMed - indexed for MEDLINE]

  18. Gibran SK, Flemming B, Stappler T, Pearce I, Groenewald C, Heimann H, Hiscott P, Wong D. Peel and peel again. Br J Ophthalmol. 2008 Mar;92(3):373-7. Epub 2007 Nov 30. PMID: 18055573 [PubMed - indexed for MEDLINE]

  19. Wong D, Kumar I, Quah SA, Ali H, Valdeperas X, Romano MR. Comparison of postoperative intraocular pressure in patients with Densiron-68 vs conventional silicone oil: a case-control study. Eye. 2007 Dec 7. [Epub ahead of print] PMID: 18064055 [PubMed - as supplied by publisher]

  20. Guerin E, Sheridan C, Assheton D, Kent D, Wong D, Grant M, Hiscott P. SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation. Microvasc Res. 2008 Apr;75(3):302-7. Epub 2007 Dec 23. PMID: 18234239 [PubMed - indexed for MEDLINE]

Top

2006

  1. Wong D, Kyle G. Some ethical considerations for the "off-label" use of drugs such as Avastin. Br J Ophthalmol 2006;90(10):1218-9.

  2. Wong D, Cazabon S, Ali H, Kumar I, Valldeperas X, Groenewald C, et al. Can the sequential use of conventional silicone oil and heavy oil be a strategy for the management of proliferative vitreoretinopathy? Ann Acad Med Singapore 2006;35(3):181-4.

  3. Wong D. Auditing cataract surgery nationwide. Br J Ophthalmol 2006;90(7):817.

  4. Valldeperas X, Romano M, Wong D. Resolution of cystoid macular oedema after retinal detachment repair: is intravitreal triamcinolone useful? Eye 2006;20(11):1321-2.

  5. Steven P, Laqua H, Wong D, Hoerauf H. Secondary paracentral retinal holes following internal limiting membrane removal. Br J Ophthalmol 2006;90(3):293-5.

  6. Sheridan CM, Rice D, Hiscott PS, Wong D, Kent DL. The presence of AC133-positive cells suggests a possible role of endothelial progenitor cells in the formation of choroidal neovascularization. Invest Ophthalmol Vis Sci 2006;47(4):1642-5.

  7. Guerin EP, Wong D, Silvestri G, Hiscott PS. Cytokeratin subtyping to distinguish reactive and neoplastic RPE cells. Br J Ophthalmol 2006;90(6):801-2.

  8. Manousakis E, Groenewald C, Wong D. New Heavy Silicone oil Densiron 68: surgical removal. Greek Annals of Ophthalmology 2006;15(42),No 2.

Top

-- Back to Home --